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FEATURE

Impact of Electronic qSOFA-Based Sepsis Screening on In-Hospital Mortality: Insights from a Stepped-Wedge Cluster Randomized Trial

Time to read: 03:01. To determine whether electronic sepsis screening, compared with no screening, reduces 90-day in-hospital mortality among patients admitted to hospital wards.

Source: JAMA

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Study Explores the Link Between Antibiotic Use and Cognitive Decline in Older Adults

Time to read: 02:49. This study aimed to examine the prospective association of antibiotics with cognitive aging among initially healthy older adults.

Source: Neurology

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Impact of early antibiotic exposure on childhood atopic dermatitis, asthma, and inhaled corticosteroid use

Time to read 02:38.Early antibiotic exposure, both in the neonatal period and before six months, is associated with an increased risk of atopic dermatitis, asthma, and the need for inhaled corticosteroids later in childhood. However, neonatal antibiotic exposure due to confirmed infection does not seem to be linked to asthma or corticosteroid use.

Source: European Journal of Paediatrics

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Harnessing Machine Learning to Decode Cholera: A Study of Vibrio cholerae’s Evolutionary Adaptations in Bangladesh

Time to read: 1:52 Genomic analysis revealed unique traits of Vibrio cholerae lineages linking recent mutations to increased virulence, transmission, and disease severity

Source: Nature Communciation

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The impact of Azithromycin distribution on childhood mortality in Sub-Saharan Africa

Time to read: 01:15. The findings of this study suggest that distributing azithromycin to children aged 1 to 59 months is more effective at reducing mortality than limiting treatment to infants.

Source: NEJM

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Immune responses of patients on maintenance hemodialysis after infection by SARS-CoV-2: a prospective observational cohort study

n patients with acute COVID-19 undergoing chronic haemodialysis (CHD), immune system dysfunction and inflammation are heightened, perpetuating chronic systemic inflammation. The primary study endpoint was the differences between cytokines and white blood cell subsets between patients on CHD who had COVID-19, and comparators on CHD who were uninfected.

Source: BMC Infectious Diseases

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Comparative study of diagnostic efficacy of sputum and bronchoalveolar lavage fluid specimens in community-acquired pneumonia children treated with fiberoptic bronchoscopy

This study examined 142 hospitalized children undergoing bronchoalveolar lavage, analysing paired sputum and BALF samples via multiplex PCR to detect nine viruses and two atypical bacteria.

Source: BMC Infectious Diseases

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Immunogenicity of novel oral poliovirus vaccine type 2 administered concomitantly with bivalent oral poliovirus vaccine: an open-label, non-inferiority, randomised, controlled trial

The development of Novel Oral Poliovirus Vaccine Type 2 (nOPV2) involved genetic modifications to enhance its stability and reduce the risk of triggering new outbreaks of circulating vaccine-derived Poliovirus Type 2.

Source: The Lancet

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WHO Virtual Press Conference on global health issues - Malaria Update

Gavi and UNICEF & WHO will shortly announce the allocation of 18 million doses of the RTS,S malaria vaccine to 12 countries in Africa.

Source: WHO Press Briefing

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Deep Learning Detection of Active Pulmonary Tuberculosis at Chest Radiography Matched the Clinical Performance of Radiologists.

Google's artificial intelligence (AI) technology is being used to enhance the diagnosis of tuberculosis (TB). The technology, known as DeepMind, has been trained to analyze chest X-rays and detect signs of TB with high accuracy.

Source: Radiology

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Efficacy and safety of sulbactam–durlobactam versus colistin for the treatment of patients with serious infections caused by Acinetobacter baumannii–calcoaceticus complex: a multicentre, randomised, active-controlled, phase 3, non-inferiority clinical trial (ATTACK)

An urgent need exists for antibiotics to treat infections caused by carbapenem-resistant Acinetobacter baumannii–calcoaceticus complex (ABC).The article presents the findings of a phase 3 clinical trial comparing the efficacy and safety of the antibiotic combination sulbactam-durlobactam to colistin for the treatment of serious infections caused by carbapenem-resistant Acinetobacter baumannii-calcoaceticus complex (ABC).

Source: Lancet Infectious Diseases

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CRISPR-Cas systems for diagnosing infectious diseases

The review provides an overview of different classes and types of CRISPR-Cas systems, including their mechanisms and functions, and discusses the pros and cons of using these systems for developing molecular diagnostic tests.

Source: Methods

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Cardiovascular symptom phenotypes of post-acute sequelae of SARS-CoV-2

This study published in the International Journal of Cardiology examined cardiovascular changes in patients with post-acute sequelae of SARS-CoV-2 infection.

Source: International Journal of Cardiology

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