Acute COVID-19 infection has significantly impacted global public health, leading to millions of confirmed cases and deaths worldwide. It has become evident that COVID-19 affects the respiratory system and various organs and systems, resulting in a wide range of clinical manifestations. Some individuals experience prolonged symptoms and complications after the acute phase of the illness, leading to the concept of long COVID.
Long COVID is characterized by persistent symptoms lasting more than four weeks after SARS-CoV-2 infection, and it can develop regardless of the severity of the initial infection. Cardiovascular involvement is a significant concern, as it can have a negative impact on the prognosis and pre-existing cardiovascular conditions. However, the full spectrum of cardiovascular issues associated with post-COVID-19 syndrome is not yet well-established.
This study, published in the International Journal of Cardiology, examined cardiovascular changes in patients with post-acute sequelae of SARS-CoV-2 infection. The study included 100 adult patients referred to a specialized clinic for post-COVID cardiology evaluation and treatment. The patients presented with various cardiovascular symptoms, including chest pain, palpitations, dyspnea on exertion, and fatigue. Blood pressure and heart rate were slightly elevated compared to baseline, and some patients had abnormal findings on cardiac imaging, such as reduced left ventricular function and myocarditis.
The authors suggest that cardiovascular symptoms in post-COVID-19 patients may be accompanied by mild cardiac abnormalities. However, further research is needed to better understand these cardiovascular changes' underlying mechanisms and long-term implications. Additionally, the impact of COVID-19 vaccination on the cardiovascular sequelae of the disease requires further investigation.
Long COVID continues to burden individuals and healthcare systems significantly, affecting morbidity, mortality, and quality of life.
Understanding the pathophysiology of post-acute sequelae of SARS-CoV-2 infection is crucial for managing these long-term effects of COVID-19 to improve patient outcomes.
Mahmoud, Z., East, L., Gleva, M., Woodard, P. K., Lavine, K., & Verma, A. K. (2022). Cardiovascular symptom phenotypes of post-acute sequelae of SARS-CoV-2. International journal of cardiology, 366, 35–41. https://doi.org/10.1016/j.ijcard.2022.07.018