Clinical Trial WATCH | Ophthalmology

Risk of Nonarteritic Anterior Ischemic Optic Neuropathy in Patients Prescribed Semaglutide

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Published on MedED: 21 August 2024
Source: JAMA Ophthalmology
Date Originally Published: 3 July 2024
Type of article: Clinical Trial WATCH
MedED Catalogue Reference: MOCL004 

Category: Ophthalmology
Category Cross-reference: 
Gerontology, Diabetes
Keywords: semaglutide, TD2, Obestify, optic neuropathy, NAION, nonarteritic anterior ischemic optic neuropathy


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This summary is intended to provide a snapshot of the original research. It is in no way a substitute for the original research article, nor is it intended to be a complete reflection of the original research. 

Originally published in JAMA Ophthalmology, 3 July 2024

This retrospective matched cohort study examined the association between semaglutide and nonarteritic anterior ischemic optic neuropathy (NAION).

Propensity matching was used to evaluate the risk of NAION with semaglutide use in individuals with type 2 diabetes or in those who were overweight/obese, adjusting for covariates and contraindications.

16,827 patients were included in the study: 
710 had type 2 diabetes: 194 were on semaglutide and 516 on non–GLP-1 RA antidiabetic medications (median age 59). 
979 patients were considered overweight or obese (median age 47), 361 of whom receiving semaglutide and 618 were on non–GLP-1 RA weight-loss medications.
 
In the type 2 diabetes cohort, 17 NAION events were determined in the semaglutide group versus 6 in the non–GLP-1 RA group (hazard ratio [HR], 4.28; 95% CI, 1.62-11.29; P<0.001).
 
In the overweight or obese cohort, 20 NAION events occurred in the semaglutide group versus 3 in the non–GLP-1 RA group (HR, 7.64; 95% CI, 2.21-26.36; P<0.001). 

The researchers concluded that the data indicates a clear association between an increased risk of NAION in patients using semaglutide and warrants further investigation.

 


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