In Brief | Association Between the First-Hour Intravenous Fluid Volume and Mortality in Pediatric Septic Shock
Published on MedED: 14 June 2023
Type of article: In Brief
MedED Catalogue Reference: MPIB001
Sources: Annals of Emergency Medicine
Type of article: In Brief
MedED Catalogue Reference: MPIB001
Sources: Annals of Emergency Medicine
Published on MedED: 14 June 2023
This retrospective cohort study aimed to determine if receiving more than or equal to 30 mL/kg of intravenous fluid within the first hour of arrival at the emergency department (ED) is linked to sepsis-attributable mortality in children with hypotensive septic shock. The study was conducted in fifty-seven EDs as part of a quality improvement collaborative.
The researchers measured two outcomes:
- Patients younger than 18 years old, with hypotensive septic shock, were propensity matched for the probability of receiving ≥30 ml/Kg in their first hour of admission. The sepsis-attributable mortality was then determined.
- The secondary outcome measured the sepsis-attributed mortality in children with suspected sepsis, regardless of their blood pressure, who received the same fluid regimen.
The findings were as follows:
- 26 of the 602 patients with hypotensive septic shock who received≥30 ml/kg of fluid in the first hour had 30-day sepsis-attributable mortality, compared with 25 patients who received less than 30 mL/kg
- Among the patients with suspected sepsis, regardless of blood pressure, 30-day sepsis-attributable mortality was 3.0% in those receiving an IV bolus of ≥30 ml/kg compared to 2.0% in those receiving less than 30 ml/kg.
The researchers concluded that children in hypotensive septic shock given an intravenous bolus of more than or equal to 30ml/kg within their first hour of admission were not at increased mortality risk compared to children who received a lower IV bolus.
Access the original article
Disclaimer
This article is compiled from a variety of resources researched and compiled by the contributor. It is in no way presented as an original work. Every effort has been made to correctly attribute quotes and content. Where possible all information has been independently verified. The Medical Education Network bears no responsibility for any inaccuracies which may occur from the use of third-party sources. If you have any queries regarding this article contact us
Fact-checking Policy
The Medical Education Network makes every effort to review and fact-check the articles used as source material in our summaries and original material. We have strict guidelines in relation to the publications we use as our source data, favouring peer-reviewed research wherever possible. Every effort is made to ensure that the information contained here is an accurate reflection of the original material. Should you find inaccuracies, out of date content or have any additional issues with our articles, please make use of the contact us form to notify us.
