MedED Archive
Infectious Diseases
Clinical Summaries & Narrative Reviews ArchiveEvery Infectious Diseases clinical summary and narrative review in one place: in-depth, evidence-based coverage of the research shaping everyday practice.
Is Azithromycin Still Enough? Mapping Macrolide Resistance in Bordetella pertussis
Time to read: 11:00. hree decades of susceptibility data show that macrolide-resistant pertussis has moved from a curiosity to the dominant strain in parts of China, while resistance elsewhere may simply be going unmeasured. What does that mean for empirical treatment?
Source: Epidemiology and Infection
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Is the Gut a Hidden Engine of Antimicrobial Resistance?
Time to read: 11:00. The intestinal microbiota is not only a casualty of antibiotic therapy but also a reservoir and exchange hub for resistance genes. This review examines how that happens, what drives it, and which microbiome-directed strategies might help.
Source: Annals of Medicine
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Tuberculosis Strain Discordance Among Household Contacts: What Does It Tell Us?
Time to read: 09:00. When two members of a household develop tuberculosis, it is natural to assume one infected the other. Molecular strain typing frequently shows otherwise, with implications for where tuberculosis control efforts are directed.
Source: The Lancet Infectious Diseases
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How High Is Antimicrobial Resistance in Africa, Really? Evidence from the Largest AMR Dataset Assembled on the Continent
Time to read: 06.40
Source: PLOS Medicine
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Promising Oral Regimens Offer New Hope for Rifampin-Resistant Tuberculosis Treatment
Time to read: 07:10. The endTB Phase 3 clinical trial aimed to find shorter, effective, and safe treatment regimens for rifampin-resistant tuberculosis by using newer drugs like bedaquiline and delamanid, along with repurposed drugs such as clofazimine and linezolid.
Source: NEJM
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Antivirals for treatment of severe influenza: a systematic review and network meta-analysis of randomised controlled trials
Time to read: 10:57. In this study, researchers of this study, Gao & Guyatt et al. aimed to determine the optimal antiviral drug for the treatment of severe influenza and to support the updated WHO influenza guidelines (September 13, 2024).
Source: The Lancet
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Prescribing patterns of echinocandins in adult patients in a private hospital in Gauteng, South Africa
The Candida species group is responsible for a fourth of all hospital-acquired infections. While Candida albicans accounts for the majority of these infectious, the number of patients infected with non-albicans Candidas – such as Candida glabrata, Candida parapsilosis, Candida krusei and Candida tropicalis - is steadily growing. The researchers of this study, Grey et al., sought to determine whether South African doctors comply with the available guidelines.
Source: Southern African Journal of Infectious Diseases,
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Candida Auris: priority pathogen on the march
Keywords associated with this article: sepsis, candidemia, candida auris, COVID, infection control, WHO, fungal infection, antimicrobial, multi-drug resistant
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