Released by WHO, 13 September 2024
The updated WHO guidelines for influenza therapeutics reflect the evolving evidence from recent randomized controlled trials.
Expanding on the previous focus on severe influenza, these guidelines now cover both severe and non-severe cases, including recommendations for antiviral use to prevent infection within 48 hours of exposure. The update applies to seasonal, pandemic, and zoonotic influenza strains like H5N1, H5N6, and H7N9.
It also provides baseline risk estimates for hospitalization and death, along with definitions for high-risk patients, aiming to guide clinicians in appropriately targeting treatment and prevention strategies.
This guideline provides recommendations on the following:
• Treatment with antivirals for both severe and non-severe influenza;
• Treatment with adjunctive therapies for patients with severe influenza, including corticosteroids, non-steroidal anti-inflammatory drugs (NSAIDs), macrolides and passive immune therapy;
• Use of diagnostic testing strategies to guide treatment of patients with, or at risk of, influenza virus infection;
• Use of antivirals to prevent symptomatic influenza;
• Use of concomitant antibiotics in patients with non-severe influenza.
This publication updates the document published in 2022, “Guidelines for the clinical management of severe illness from influenza virus infections.”
Download the Clinical Guideline Update
World Health Organisation : Clinical Practical Guidelines for Influenza, 13 September 2024 (PDF)
Access the Original Press Release
13 September 2024 | WHO updates influenza care guidelines, includes recommendations for viruses with pandemic potential
Access more resources related to Influenza
Influenza Guidelines (South Africa)
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