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Paternal Preconception Hepatitis B Virus Infection and Risk of Congenital Heart Disease in Offspring

Time to read: 0 minutes, 57 seconds.
 
Published on MedED: 22 August 2024
Source: JAMA Paediatrics
Date Originally Published: 19 August 2024
Type of article: Clinical Trial Watch
MedED Catalogue Reference: MPLCT011 
Category: Paediatrics & Neonatology
Category Cross-reference: Infectious Diseases
Keywords: hepatitis B, congenital heart disease, maternal wellbeing, neonatal, paediatrics


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This summary is intended to provide a snapshot of the original research. It is in no way a substitute for the original research article, nor is it intended to be a complete reflection of the original research. 

Originally published in JAMA Paediatrics,19 August 2024
 

Previous studies have linked maternal hepatitis B virus (HBV) infection with congenital heart diseases (CHDs) in offspring, but the association with paternal preconception HBV infection was less documented. This retrospective cohort study, utilising data from the Free Preconception Checkup Project (NFPCP) in mainland China, investigated this association. 
 
Male participants, whose wives were aged 20 to 49 years and who were HBV-negative and had conceived within a year after their pre-pregnancy exam were enrolled in the study.
 
The primary exposure was paternal preconception HBV infection status—uninfected, previous infection, or new infection—while maternal HBV status was classified as immune or susceptible. 
 
The researchers recorded that among the 30,047,924 couples enrolled:
• Paternal HBV infection was associated with a 40% increased risk of CHDs irrespective of maternal HBV immune status.
• The risk of CHDs in offspring was similar for previously HBV-infected husbands, whether wives were susceptible or immune.  
• Offspring of couples with newly HBV-infected husbands and immune wives had a significantly higher risk, whereas no increased risk was found with immune susceptible wives. 
• Maternal immune status did not interact with paternal HBV infection. 
 
The findings highlight the need for personalised reproductive guidance, emphasising HBV screening and prevention for both partners.
 

 


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