Clinical Trial WATCH | Ophthalmology

0.01% Atropine Eye Drops in Children With Myopia and Intermittent Exotropia: The AMIXT Randomized Clinical Trial

This summary is intended to provide a snapshot of the original research. It is in no way a substitute for the original research article, nor is it intended to be a complete reflection of the original research. 

Originally published in JAMA Ophthalmology, 3 July  2024

This placebo-controlled, double-masked, randomized trial assessed the efficacy and safety of 0.01% atropine eye drops for controlling myopia progression and managing intermittent exotropia (IXT) in children aged 6 to 12 years.

The study included 300 children (50.1% male, mean age 9 years), randomly assigned in a 2:1 ratio to receive either 0.01% atropine (66.7%, 200 children) or placebo (33.3%, 100 children) eye drops, administered nightly for 12 months.

At the end of the study, the atropine group showed slower spherical equivalent progression and axial length elongation compared to the placebo group, with mean changes of −3.06 D versus 0.12 D, respectively. The atropine group also experienced a reduction in near-magnitude exodeviation, whereas the placebo group saw an increase.

The incidence of photophobia and blurred near vision was similar between groups (6.0% vs. 8.0% and 6.0% vs. 7.0%, respectively).

These findings support the use of 0.01% atropine eye drops to slow the progression of myopia while minimally affecting exotropia and binocular vision.


Chinese Clinical Trial Registry Identifier: ChiCTR2000039827.

Back to top 

Disclaimer
This article is compiled from various resources researched and compiled by the contributor. It is in no way presented as an original work.  Every effort has been made to attribute quotes and content correctly. Where possible,  all information has been independently verified. The Medical Education Network bears no responsibility for any inaccuracies which may occur from the use of third-party sources. If you have any queries regarding this article contact us 

Fact-checking Policy
The Medical Education Network makes every effort to review and fact-check the articles used as source material in our summaries and original material. We have strict guidelines in relation to the publications we use as our source data, favouring peer-reviewed research wherever possible. Every effort is made to ensure that the information contained here is an accurate reflection of the original material. Should you find inaccuracies, out of date content or have any additional issues with our articles, please make use of the contact us form to notify us.