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Progressive accumulation of hyperinflammatory NKG2D low NK cells in early childhood severe atopic dermatitis
Source: ScienceImmunology
Date Originally Published: 9 February 2024
Type of article: Clinical Trial Watch
MedED Catalogue Reference: MGCW008
Category: Paediatrics & Neonatology
Category Cross-reference: Dermatitis, Immunology
Keywords: atopic dermatitis, autoimmune, tumour necrosis factor
This summary is intended to provide a snapshot of the original research. It is in no way a substitute for the original research article, nor is it intended to be a complete reflection of the original research.
Originally published in ScienceImmunology, 9 February 2024
Atopic dermatitis (AD) often precedes allergies like food allergy and asthma, with reduced natural killer (NK) cell frequency contributing to AD. In a longitudinal study of children with AD, NK cells with low NKG2D expression increased over time, correlating with severe AD and allergen sensitivity. This was prominent in children sensitized to food and aeroallergens, increasing asthma risk.
Longitudinal analysis showed decreased NKG2D with persistent sensitization, indicating impaired skin barrier function. Despite low NKG2D, NK cells released more tumour necrosis factor–α, suggesting altered functional responses. These findings highlight a mechanism for allergic comorbidity in AD and define a severe AD endotype.
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