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Association between admission haemoglobin level and prognosis in sepsis patients based on a critical care database 

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Originally published in Nature, 3 March 2024

In this retrospective study, the association between admission haemoglobin levels and clinical outcomes in sepsis was explored. 

The cohort comprised 6249 septic patients, among whom there was a 30.18% 30-day mortality rate. Three models were applied: a crude model, Model I (adjusted for gender and age), and Model II (adjusted for all potential confounders). 

Each model revealed a decrease in the odds ratio (OR) of 30-day mortality with a 1 g/dl increase in haemoglobin level. Model II demonstrated the most significant decrease, with an OR of 0.87 (95% CI 0.79–0.95, P = 0.0020).  A non-linear relationship was observed in the smooth fitting curve, indicating a turning point at 7.2 g/dl.  Patients with haemoglobin levels ≥ 7.2 g/dl experienced a 32% decrease in the risk of 30-day mortality compared to those with levels < 7.2 g/dl (OR = 0.68, 95% CI 0.51–0.93, P = 0.0142). 

The findings suggest potential benefits of individualised haemoglobin supplementation for septic patients with levels below 7.2 g/dl.
 

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